If they have time, astronauts and cosmonauts will look to plug the leak or close the hatch to the leaking section of the station. (That is how they dealt with a minor leak in the station’s PrK module for a number of years, and it basically worked.) Remember, though, that this is the worst-case scenario, and our crew will run into a hard deadline. Once pressure falls to around 490 mm Hg, NASA says, critical systems risk breaking down. Astronauts could suffer hypoxia, oxygen deprivation so debilitating they could become delirious. It will be a heart-wrenching call, but if nothing else can be done, the crew will need to go to their crew vehicles and leave the ISS.
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Isaacman said the current architecture was "not a pathway to success."