A key part of the Orion spacecraft that the astronauts will be flying in was made in Bremen in Germany.
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The most turbulent flight routes in North America are over Colorado, where the prevailing winds from the west barrel into the high peaks of the Rockies and tumble onto the High Plains below. One morning this fall, on a stubbly brown field in Boulder, a glider pilot named Dan Swenson stared up at the sky and shook his head. A vast, lens-shaped cloud hung above us like an alien mother ship. It stretched from the foothills of the Front Range, in the west, to the Laramie Mountains, in the north, its pale upper reaches darkening to a gunmetal gray along the bottom. “So, what’s with this?” he said. He glanced over at Jordon Griffler, the scraggly young pilot who would tow Swenson’s glider into the sky with his single-prop plane. Griffler shrugged and took a bite of a bagel. “You can ride that all the way to Wyoming,” he said. Swenson shook his head again: “Holy cow!”
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A different sequencing method that chemically cleaved DNA at specific bases, developed by Allan Maxam and Walter Gilbert, was the dominant technology into the 1980s. Radiolabeled DNA samples were incubated in four separate reactions, each of which contained a chemical that cleaved after a different nucleotide — either A/G, G, C, or C/T. By adding the right amount of each chemical, it was possible to produce different fragments chopped off at each individual base. The sequence could then be read using gel electrophoresis and autoradiography. Maxam–Gilbert sequencing was easier than the plus and minus method to run and interpret, but was eventually surpassed by Sanger’s chain termination method, which molecular biologists found both technically preferable and more “elegant” since it mirrored the natural copying of DNA.
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